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Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Upper Respiratory Drugs: Decongestants01:27

Upper Respiratory Drugs: Decongestants

Decongestants are a class of medications used primarily to alleviate nasal congestion, a common symptom resulting from allergies, colds, sinusitis, and other upper respiratory tract infections. These drugs work by activating α-adrenergic receptors, constricting small blood vessels in the nasal membranes. This action results in the opening of clogged nasal passages, thereby facilitating sinus drainage and relieving congestion.
Most decongestants are readily available over-the-counter in various...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by anesthetizing...
Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: Jun 3, 2026

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Intranasal ciclesonide for allergic rhinitis.

Ben Williams1, William B Smith, Frank E Kette

  • 1Department of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide South Australia.

Journal of Asthma and Allergy
|March 26, 2011
PubMed
Summary
This summary is machine-generated.

Ciclesonide, a novel topical corticosteroid, is effective for allergic rhinitis but lacks demonstrated superiority over existing treatments. Further research is needed to clarify its place in therapy, especially for children.

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Area of Science:

  • Pharmacology
  • Allergology
  • Respiratory Medicine

Background:

  • Ciclesonide is a novel pro-drug corticosteroid designed for topical application.
  • Its properties include local activation, lipid conjugation for retention, and high protein binding, aiming for selective activity and reduced side effects.
  • It is approved for asthma and shows efficacy in allergic rhinitis treatment.

Purpose of the Study:

  • To evaluate the efficacy and safety of ciclesonide for allergic rhinitis.
  • To compare ciclesonide with existing topical corticosteroids.
  • To assess its utility in pediatric allergic rhinitis.

Main Methods:

  • Review of double-blind trials evaluating ciclesonide in seasonal and perennial allergic rhinitis.
  • Analysis of data regarding efficacy and adverse effects compared to other nasal corticosteroids.
  • Examination of pediatric study outcomes.

Main Results:

  • Ciclesonide has demonstrated efficacy in treating allergic rhinitis.
  • No current data show superiority over existing nasal topical corticosteroids in efficacy or safety.
  • Efficacy in children with rhinitis has not been clearly established.

Conclusions:

  • Ciclesonide is an effective treatment option for allergic rhinitis.
  • Its comparative advantage over other topical corticosteroids remains undetermined.
  • Further investigation is required to establish its role in pediatric allergic rhinitis management.