gamma IFN receptor expression in haemic malignancies

gamma Interferon receptor (gamma IFNR) expression was examined by Scatchard analysis in 49 patients with various haemic malignancies. In chronic lymphocytic leukaemia (CLL) (20 cases) expression was variable but generally low (0-1600 receptors/cell) and was not related to clinical stage. In hairy-cell leukaemia (HCL) (n = 6), prolymphocytic leukaemia (PLL) (n = 1) and acute lymphoblastic leukaemia (ALL) (n = 4) expression was again variable but was significantly higher than in CLL (500-4500 receptors/cell). In the myeloid proliferations (n = 18) receptor numbers were significantly higher than in the lymphoproliferative disorders as a whole (1000-30,000) and the highest level of expression was observed in primitive monocytoid proliferations.