Related Experiment Video
Updated: Jun 3, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Protective effect of low serum thyroid hormone concentration on occurrence of functional delayed kidney allograft
R Hekmat1, Z Javadi, M L Javain
1Mashhad University of Medical Sciences, Ghaem Hospital, Department of Nephrology, Mashhad, Iran. drhekmatreza@yahoo.com
Background:
Thyroid hormones affect the functioning of a number of organs and may alter kidney function. In contrast, the thyroid gland may be influenced by renal dysfunction. The present study evaluated triiodothyronine (T3), thyroxine, and thyroid-stimulating hormone concentrations before and early after transplantation relative to the occurrence of delayed graft function.
Patients And Methods:
Eighty-seven consecutive patients (52 male and 37 female patients) undergoing kidney transplantation were entered in this cross-sectional study, and T3, thyroxine, and thyroid-stimulating hormone concentrations were measured on the day before transplantation and on days 1, 3, and 7 after engraftment.
Results:
The mean (SD) serum T3 concentration was significantly greater before transplantation in patients with delayed graft function compared with those with normally functioning kidney allografts (129±31.44 ng/dL versus 102±36.77 ng/dL; P-value=.048). Lower T3 concentration values were predictive of delayed graft function. It was hypothesized that early after transplantation, in patients with uremia, a low T3 concentration confers a protective effect against ischemia-reperfusion injury, mitigating a hypercatabolic state.
Conclusion:
Low serum T3 concentration in patients with uremia before transplantation may have protective effects against the hypercatabolic uremic state and ischemia-reperfusion injury early after engraftment.
Related Concept Videos
Kidney Transplant I: Introduction
Kidney Transplant III: Nursing Management
Kidney Transplant II: Surgical Procedure
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury III: Clinical Manifestations