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Updated: Jun 3, 2026

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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition
Xiaoguang Lei1, Samuel J Danishefsky
1Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, New York 10027.
Advanced Synthesis & Catalysis
|March 29, 2011
Abstract:
The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol (5), is described. The key step involves a fragment coupling using "click chemistry." The preliminary biological evaluation of triazole-cycloproparadicicol is also reported.
