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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...

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Related Experiment Video

Updated: Jun 3, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Microangiopathic disorders in pregnancy.

Salley G Pels1, Michael J Paidas

  • 1Section of Hematology Oncology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520-8063, USA. salley.pels@yale.edu

Hematology/Oncology Clinics of North America
|March 30, 2011
PubMed
Summary

Pregnancy-related microangiopathic disorders, causing low platelets and red blood cell destruction, require prompt diagnosis and multidisciplinary care to prevent severe maternal and fetal complications.

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Last Updated: Jun 3, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Pathophysiology

Background:

  • Microangiopathic disorders are characterized by thrombocytopenia, hemolytic anemia, and multiorgan damage.
  • These conditions pose significant diagnostic and therapeutic challenges during pregnancy due to overlapping symptoms and varied treatments.
  • Maternal and fetal outcomes can be devastating if misdiagnosed or improperly managed.

Purpose of the Study:

  • To highlight the importance of understanding microangiopathic disorders in pregnancy.
  • To emphasize the need for collaborative obstetric and hematology management.
  • To underscore the potential for improved outcomes with advancing knowledge of disease pathophysiology.

Main Methods:

  • Review of clinical scenarios and treatment approaches for pregnancy-associated microangiopathic disorders.
  • Analysis of diagnostic and therapeutic challenges.
  • Discussion of the impact of pathophysiology on patient outcomes.

Main Results:

  • Microangiopathic disorders in pregnancy present complex diagnostic and therapeutic dilemmas.
  • Effective management necessitates a combined approach from obstetric and hematology specialists.
  • Understanding the underlying pathophysiology is crucial for developing new diagnostic tools and therapies.

Conclusions:

  • Early and accurate diagnosis of microangiopathic disorders in pregnancy is critical.
  • Multidisciplinary care involving obstetric and hematology teams is essential for optimal maternal and fetal outcomes.
  • Continued research into disease mechanisms will drive advancements in diagnosis and treatment.