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Updated: Jun 3, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
[Ocular pseudoexfoliation syndrome].
Jasmina Dordević-Jocić1, Gordana Zlatanović, Dragan Veselinović
1Klinicki centar Nis, Nis. jdjordjevic.jocic@gmail.com
Medicinski Pregled
|March 31, 2011
Summary
Pseudoexfoliation syndrome involves abnormal material buildup in ocular tissues. Early detection and management are crucial for preventing surgical complications and associated systemic risks.
Area of Science:
- Ophthalmology
- Genetics
- Molecular Biology
Context:
- Pseudoexfoliation syndrome (PEX) is an age-related disorder characterized by abnormal extracellular fibrillar material deposition.
- PEX affects ocular tissues and has recognized systemic associations, including cardiovascular and cerebrovascular conditions.
Purpose:
- To provide an updated review of ocular and systemic manifestations, diagnosis, management, and molecular pathophysiology of pseudoexfoliation syndrome.
- To highlight recent advancements in understanding PEX and its clinical implications.
Summary:
- Recent progress has improved clinical management through better understanding of PEX effects on ocular tissues, refined diagnostic criteria, new treatments, and preventive strategies.
- The pathogenesis involves an elastic microfibrillopathy with roles for TGF-β, MMPs, and oxidative stress.
- Systemic associations with cardiovascular diseases warrant integrated management approaches.
Impact:
- Improved clinical management and surgical outcomes for patients with pseudoexfoliation syndrome.
- Enhanced understanding of PEX pathophysiology may lead to novel therapeutic targets.
- Physicians are alerted to increased surgical risks and the importance of PEX in glaucoma detection.
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