Efficacy of capsicum oleoresin nanocapsules formulation by the modified emulsion-diffusion method
Suvimol Surassmo1, Sang-Gi Min, Piyawan Bejrapha
1Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 143-701, Korea.
Journal of Nanoscience and Nanotechnology
|March 31, 2011
Summary
High pressure homogenization significantly improved capsicum oleoresin nanocapsules (NCs) using the modified-emulsion-microfluidization-diffusion (MEMD) method. MEMD yielded smaller, more stable NCs with higher encapsulation efficiency and controlled release.
Area of Science:
- Food Science and Technology
- Materials Science
- Chemical Engineering
Background:
- Capsicum oleoresin encapsulation is crucial for stabilizing its properties and enhancing its application.
- Traditional methods for creating nanoemulsions and nanocapsules often face challenges in achieving optimal particle size, stability, and encapsulation efficiency.
- High-pressure processing offers a potential avenue for improving nanoencapsulation techniques.
Purpose of the Study:
- To investigate the impact of high-pressure homogenization on the physico-chemical properties of capsicum oleoresin loaded nanoemulsions (NE) and nanocapsules (NCs).
- To compare different methods of applying high-pressure processing within an emulsion-diffusion framework: conventional-emulsion-diffusion (CED), modified-emulsion-microfluidization-diffusion (MEMD), and modified-emulsion-diffusion-microfluidization (MEDM).
- To evaluate the efficacy of microfluidization in enhancing the performance of nanocapsules.
Main Methods:
- Preparation of capsicum oleoresin loaded nanocapsules using three distinct emulsion-diffusion based methods: CED, MEMD, and MEDM.
- Application of high-pressure processing at different stages of the emulsion-diffusion method.
- Characterization of nanocapsules, including particle size, surface tension, color, encapsulation efficiency, and release rate.
Main Results:
- The MEMD method produced homogeneous nanocapsules with the smallest particle size compared to CED.
- MEMD resulted in a surface tension of 36.5 mN/m and improved the color of the encapsulated capsicum oleoresin.
- MEMD achieved a high encapsulation efficiency (around 95%) and a slow release rate, while MEDM showed poor homogeneity, low efficiency, and rapid initial release.
Conclusions:
- Microfluidization is a promising technique for improving the physical properties and encapsulation efficiency of nanocapsules when integrated appropriately into emulsion-diffusion methods.
- The modified-emulsion-microfluidization-diffusion (MEMD) method demonstrated superior performance in creating stable and effective capsicum oleoresin nanocapsules.
- Optimizing the combination of microfluidization and emulsion-diffusion techniques is key to achieving desired nanocapsule characteristics.
