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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: Jun 3, 2026

Isolation of Human BAMBIhighMFGE8high Umbilical Cord-Derived Mesenchymal Stromal Cells
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Isolation of Human BAMBIhighMFGE8high Umbilical Cord-Derived Mesenchymal Stromal Cells

Published on: January 10, 2025

[Human mesenchymal stem cell biology].

Pierre Charbord1, Louis Casteilla

  • 1Inserm U972, bâtiment Gregory Pincus, hôpital de Bicêtre, 80, avenue du Général Leclerc, 94276 Le Kremlin Bicêtre Cedex, France. pierre.charbord@inserm.fr

Medecine Sciences : M/S
|March 31, 2011
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells from bone marrow and adipose tissue share key traits. Their therapeutic potential lies in tissue repair via differentiation and secreting beneficial factors for inflammation and tissue regeneration.

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Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
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Last Updated: Jun 3, 2026

Isolation of Human BAMBIhighMFGE8high Umbilical Cord-Derived Mesenchymal Stromal Cells
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Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Cell therapy

Background:

  • Mesenchymal stem cells (MSCs) are crucial for tissue repair.
  • Adipose-derived stem cells (ADSCs) offer an alternative source of MSCs.
  • Understanding their properties is key for therapeutic applications.

Purpose of the Study:

  • To summarize the characteristics of bone marrow-derived MSCs and ADSCs.
  • To detail criteria for stemness (multipotency, self-renewal, plasticity).
  • To explore repair mechanisms in cell therapy.

Main Methods:

  • Comparative overview of MSC and ADSC properties.
  • Analysis of stemness criteria.
  • Review of therapeutic repair mechanisms.

Main Results:

  • Both cell types exhibit multipotency, self-renewal, and plasticity.
  • They possess hematopoiesis-supportive and immunosuppressive functions.
  • Repair involves tissue repopulation and secretion of bioactive factors.

Conclusions:

  • MSCs and ADSCs are promising for cell therapy.
  • Their therapeutic effects are mediated by differentiation and paracrine signaling.
  • Further research into their mechanisms can optimize clinical use.