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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Hepatic Portal System01:21

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...

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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

[Hepatocellular carcinoma].

David Semela1, Markus Heim

  • 1Abteilung für Gastroenterologie und Hepatologie, Universitätsspital Basel. david.semela@unibas.ch

Therapeutische Umschau. Revue Therapeutique
|April 1, 2011
PubMed
Summary
This summary is machine-generated.

Hepatocellular carcinoma (HCC) is a growing global health concern and a leading cause of cancer death. Early detection through surveillance and advancements in treatments like surgery, transplantation, and targeted therapies are improving patient outcomes.

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Area of Science:

  • Hepatology
  • Oncology
  • Gastroenterology

Context:

  • Hepatocellular carcinoma (HCC) ranks as the fifth most prevalent cancer globally and the third leading cause of cancer-related mortality.
  • The incidence of HCC is on the rise, significantly impacting patient survival, particularly among those with liver cirrhosis.
  • Early detection via surveillance in chronic liver disease patients is crucial for effective management.

Purpose:

  • This review aims to summarize recent advancements in the diagnosis and treatment of HCC.
  • To provide an overview of current therapeutic strategies for various stages of HCC.
  • To highlight the importance of ongoing research in HCC management.

Summary:

  • Early-stage HCC can be cured with surgical resection, liver transplantation, or ablative therapies.
  • Intermediate and advanced-stage HCC benefit from treatments such as chemoembolisation and the tyrosine kinase inhibitor sorafenib, improving survival rates.
  • This review consolidates recent developments in diagnostic tools and therapeutic interventions for HCC.

Impact:

  • Improved understanding of HCC diagnostics and therapeutics can lead to better patient stratification and treatment selection.
  • Advances in HCC treatment offer improved survival and quality of life for patients.
  • This review serves as a valuable resource for clinicians and researchers in the field of HCC.