Unraveling the biological roles of reactive oxygen species
Michael P Murphy1, Arne Holmgren2, Nils-Göran Larsson3
1MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK.
Abstract:
Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.
Related Concept Videos
Redox Reactions
Redox Reactions
Oxygen Requirements and Growth Patterns
Radical Autoxidation
Peroxisomes
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...


