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Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

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Protein Networks

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Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

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Related Experiment Video

Updated: Jun 3, 2026

Associated Chromosome Trap for Identifying Long-range DNA Interactions

Associated Chromosome Trap for Identifying Long-range DNA Interactions

Published on: April 23, 2011

Window into the complexities of chromosome interactomes.

A Göndör¹, A Fernandez Woodbridge, C Shi

¹Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.

Cold Spring Harbor Symposia on Quantitative Biology

|April 7, 2011

Summary

Epigenetic marks on DNA influence chromatin fiber proximity and transfer states, impacting chromosome interactions and nuclear processes like transcription and replication timing.

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Associated Chromosome Trap for Identifying Long-range DNA Interactions

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Published on: April 23, 2011

In-Nucleus Hi-C in Drosophila Cells

In-Nucleus Hi-C in Drosophila Cells

Published on: September 15, 2021

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

Area of Science:

Molecular Biology
Genetics
Cell Biology

Background:

DNA folding creates complex, mobile chromosomal structures within the interphase nucleus.
Chromosomes interact preferentially at the boundaries of chromosomal territories, suggesting neighborhood influences interactions.
The functional implications of preferred chromosomal neighborhoods are not fully understood.

Purpose of the Study:

To investigate the dual functions of epigenetic information in chromatin fiber interactions.
To understand how epigenetic marks influence proximity and transfer states between chromatin fibers.
To explore the role of chromatin movement in establishing chromosome interactomes.

Main Methods:

Utilized the H19 imprinting control region as a model system.
Employed high-throughput sequencing.
Conducted DNA fluorescence in situ hybridization (FISH) analyses.

Main Results:

Epigenetic information on chromatin fibers influences their proximity.
Epigenetic marks facilitate the transfer of epigenetic states between chromatin fibers (cis and trans).
These processes necessitate spatially and temporally restricted chromatin movements.

Conclusions:

Epigenetic marks play a crucial role in organizing chromosome interactions.
Understanding chromosome interactome mechanisms offers insights into nuclear regulatory processes.
This research sheds light on the coordination of transcriptional programs and replication timing.