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Updated: Jun 2, 2026
08:24
The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System
Published on: February 28, 2017
[Progress and application prospect of pig induced pluripotent stem cells]
Yi-Bo Yan1, Yan-Li Zhang, Wei-Wei Qi
1Center of Animal Embryo Engineering and Technology, Nanjing Agricultural University, Nanjing 210095, China. bobo10679888@163.com
Yi Chuan = Hereditas
|April 13, 2011
Summary
Induced pluripotent stem cells (iPS cells) offer a new method for reprogramming somatic cells. Pig iPS cells are advancing, promising breakthroughs in livestock breeding, conservation, and human regenerative medicine.
Area of Science:
- Stem cell biology
- Comparative genomics
Context:
- Pigs are valuable models due to their genetic similarity to humans and importance in agriculture.
- Establishing large ungulate embryonic stem cell (ES cell) lines has been challenging.
- Induced pluripotent stem cell (iPSC) technology offers a novel approach to cellular reprogramming.
Purpose:
- To review the progress of iPS cells, focusing on pig iPS cells.
- To highlight the current status and future applications of pig iPS cells.
- To provide a reference for researchers in stem cell biology and related fields.
Summary:
- Significant advancements in pig iPS cell technology are anticipated, building upon established iPSC methods.
- Pig iPS cells are expected to facilitate the development of ES cell lines in other livestock.
- The development of pig iPS cells is crucial for improving transgenic cloning efficiency in pigs.
Impact:
- Pig iPS cells offer a promising new model for human medical research and disease modeling.
- They hold potential as donor cells for human tissue and organ engineering, impacting regenerative medicine.
- Applications extend to enhancing pig breeding, conservation efforts, and the broader biomedical field.
Related Concept Videos
01:13Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
01:06Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic cells are...
01:13Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
01:22iPS Cell Differentiation
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
01:21EPS and iPS Cells in Disease Research
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
01:29Somatic to iPS Cell Reprogramming
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...