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Updated: Jun 2, 2026

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
Published on: January 29, 2018
SUMOylation and de-SUMOylation in response to DNA damage
Hong Dou1, Chao Huang, Thang Van Nguyen
1Department of Cardiology, The University of Texas, M.D. Anderson Cancer Center, TX 77030, USA.
Abstract:
To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).
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