Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A nation-wide study on snus and smoked tobacco: The Swedish Tobacco Cohort (SWETOC).

Scandinavian journal of public health·2025
Same author

Survival in myotonic dystrophy type 1: a long time follow up-study with special reference to gastrointestinal symptoms.

Upsala journal of medical sciences·2024
Same author

Colonoscopy findings after increasing two-stool faecal immunochemical test (FIT) cut-off: Cross-sectional analysis of the SCREESCO randomized trial.

Journal of internal medicine·2024
Same author

Comparison of rivaroxaban and low molecular weight heparin in the treatment of cancer-associated venous thromboembolism: a Swedish national population-based register study.

Journal of thrombosis and thrombolysis·2024
Same author

Does smoking cessation affect postoperative healing following oral surgery among smokers? - a systematic review.

BMC oral health·2024
Same author

Comparison of Clinical Outcomes in Patients with Active Cancer Receiving Rivaroxaban or Low-Molecular-Weight Heparin: The OSCAR-UK Study.

Thrombosis and haemostasis·2024
Same journal

Stress Disorders and Human Papillomavirus-Related Cancer Rates: A Population-Based Cohort Study in Denmark.

Clinical epidemiology·2026
Same journal

Making Statistics Clinically Meaningful.

Clinical epidemiology·2026
Same journal

Sensitivity of Administrative Coding for Heart Disease in Pregnancy.

Clinical epidemiology·2026
Same journal

Cohort Profile: The Central Denmark Cancer Cohort.

Clinical epidemiology·2026
Same journal

The Danish Database for Hepatitis B and C (DANHEP): A Nationwide, Prospective, Ongoing Cohort Study.

Clinical epidemiology·2026
Same journal

Pregnancy Outcomes in Women with Type 1 Diabetes by Socioeconomic and Mental Health Disadvantages.

Clinical epidemiology·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Breast cancer associated with primary hyperparathyroidism: a nested case control study.

Sophie Norenstedt1, Fredrik Granath, Anders Ekbom

  • 1Department of Molecular Medicine and Surgery.

Clinical Epidemiology
|April 14, 2011
PubMed
Summary
This summary is machine-generated.

Women with primary hyperparathyroidism (pHPT) history and breast cancer show similar prognosis and treatment response compared to those without pHPT. This suggests pHPT does not negatively impact breast cancer outcomes.

Keywords:
breast cancerprimary hyperparathyroidismprognostic factors

Related Experiment Videos

Last Updated: Jun 2, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Area of Science:

  • Endocrinology
  • Oncology
  • Epidemiology

Background:

  • Primary hyperparathyroidism (pHPT) is linked to increased breast cancer risk.
  • Underlying factors connecting pHPT and breast cancer prognosis are not well understood.

Purpose of the Study:

  • To compare prognostic and therapeutic response factors in breast cancer patients with and without a history of pHPT.
  • To investigate if a history of pHPT influences breast cancer outcomes.

Main Methods:

  • Retrospective analysis of Swedish national and regional cancer registries.
  • Comparison of 71 breast cancer patients with prior parathyroid adenomectomy against 338 matched controls.
  • Analysis of tumor characteristics, staging, hormone receptor status, lymph node involvement, survival, and cause of death.

Main Results:

  • No significant differences in tumor size, stage, lymph node metastasis, or survival were observed between groups.
  • Patients with pHPT history did not present with Stage III or IV breast cancer.
  • Mean age and time from parathyroid surgery to breast cancer diagnosis were comparable.

Conclusions:

  • Prognostic factors and response to therapy for breast cancer are similar in women with and without a history of pHPT.
  • A history of pHPT does not appear to adversely affect breast cancer prognosis based on these factors.