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Related Experiment Video

Updated: Jun 2, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Aliskiren-based stepped-care treatment algorithm provides effective blood pressure control.

D Richter¹, C Mickel, S Acharya

¹Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.

International Journal of Clinical Practice

|April 15, 2011

Summary

An aliskiren-based stepped-care regimen effectively managed mild-to-moderate hypertension, with 86% of patients reaching blood pressure goals. This treatment approach, including hydrochlorothiazide and amlodipine, proved well-tolerated and successful.

Related Experiment Videos

Last Updated: Jun 2, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Area of Science:

Cardiovascular Medicine
Pharmacology
Hypertension Management

Background:

Recent hypertension guidelines advocate individualized stepped-care treatment for mild-to-moderate cases.
Achieving blood pressure (BP) targets is crucial for patient outcomes.

Purpose of the Study:

To evaluate the probability of achieving BP targets using an aliskiren-based stepped-care regimen.
To assess the efficacy and tolerability of incremental add-on therapy in hypertension management.

Main Methods:

A 24-week, open-label, non-comparator study in mild-to-moderate hypertensive patients.
Sequential 4-week treatment periods with aliskiren, followed by hydrochlorothiazide (HCTZ), and amlodipine if needed.
Primary endpoint: cumulative probability of patients achieving target BP.

Main Results:

232 out of 256 (90.6%) patients completed the study.
The estimated cumulative probability of reaching BP target was 86.12% at study endpoint.
The stepped-care regimen was well tolerated at maximal recommended doses.

Conclusions:

An aliskiren-based stepped-care regimen, incorporating HCTZ and amlodipine, effectively achieves BP goals in approximately 90% of mild-to-moderate hypertensive patients.
This treatment strategy demonstrates significant efficacy and good tolerability for hypertension management.