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Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
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Peptide synthesis 'in water' by a solution-phase method using water-dispersible nanoparticle Boc-amino acid

Keiko Hojo1, Hideki Ichikawa, Mare Onishi

  • 1Faculty of Pharmaceutical Sciences & Cooperative Research Center of Life Sciences, Kobe Gakuin University, Chou-ku, Kobe 650-8586, Japan. hojo@pharm.kobegakuin.ac.jp

Journal of Peptide Science : an Official Publication of the European Peptide Society
|April 16, 2011
PubMed

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Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...