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Retrograde Neuroanatomical Tracing of Phrenic Motor Neurons in Mice
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Published on: February 22, 2018

Chorea caused by toxins.

Janis M Miyasaki1

  • 1Morton and Gloria Shulman Movement Disorders Centre, Krembil Neuroscience Centre, University Health Network, University of Toronto, Toronto, Canada. miyasaki@uhnresearch.ca

Handbook of Clinical Neurology
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

Toxins rarely cause chorea, but studying these cases offers insights into neurodegenerative diseases. Toxins may affect dopamine and GABA pathways, influencing movement disorders.

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Area of Science:

  • Neuroscience
  • Toxicology
  • Movement Disorders

Background:

  • Chorea is infrequently linked to toxic agents.
  • Understanding toxin-induced chorea aids research into neurodegenerative conditions.

Observation:

  • Historical examples include medieval ergotism and contemporary alcohol abuse.
  • Toxin exposure can manifest as involuntary, dance-like movements.

Findings:

  • Toxins may directly increase dopamine transmission in the mesolimbic pathway.
  • Alternatively, toxins might indirectly modulate gamma-aminobutyric acid (GABA) pathways.

Implications:

  • This review explores toxins implicated in chorea.
  • It discusses the underlying pathophysiology of toxin-related movement disorders.