Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral stimuli,...
Secondary Messengers in Hormone Action01:26

Secondary Messengers in Hormone Action

Water-soluble hormones cannot cross the plasma membrane, so they rely on protein receptors that span the membrane to trigger intracellular signaling pathways. These pathways then activate second messengers inside the cell, including cAMP or calcium ions.
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
Hormones of the Pituitary Gland01:27

Hormones of the Pituitary Gland

The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disease-related burden and treatment experience in patients with acromegaly: a gender perspective.

Journal of endocrinological investigation·2026
Same author

Marginal diffusion slope as a prognostic imaging biomarker of infiltrating phenotype in glioblastoma; A cancer imaging biomarker roadmap study.

Neuro-oncology advances·2026
Same author

Trust in medical art is the most effective coping mechanism for predicting treatment satisfaction in elective neurosurgery.

Scientific reports·2026
Same author

Impact of pain on quality of life (QoL) in patients with acromegaly: profound differences in physical and mental aspects of QoL.

Endocrine·2026
Same author

[Need for Improvement in Healthcare Provision for Rare Endocrinological Diseases in Germany Using the Example Endogenous Cushing's Syndrome].

Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·2026
Same author

Hemispheric asymmetry of [<sup>11</sup>C](<i>R)</i>PK11195 binding to translocator protein 18 kDa (TSPO) in normal brain.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2025
Same journal

HDL resuscitates cells from ferroptosis.

Trends in endocrinology and metabolism: TEM·2026
Same journal

2-Methylbutyrylcarnitine (2MBC).

Trends in endocrinology and metabolism: TEM·2026
Same journal

Decoding growth hormone actions on human growth plate stem cells.

Trends in endocrinology and metabolism: TEM·2026
Same journal

Androgen loss backfires: Brain gate for tumor immunity.

Trends in endocrinology and metabolism: TEM·2026
Same journal

Glucocorticoid resistance-induced inflammation drives cardiovascular-kidney-metabolic (CKM) syndrome pathophysiology.

Trends in endocrinology and metabolism: TEM·2026
Same journal

Hippo signalling in cellular and tissue-level metabolism across health and disease.

Trends in endocrinology and metabolism: TEM·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Ex Vivo Calcium Imaging for Visualizing Brain Responses to Endocrine Signaling in Drosophila
06:49

Ex Vivo Calcium Imaging for Visualizing Brain Responses to Endocrine Signaling in Drosophila

Published on: June 2, 2018

Visualizing hormone actions in the brain.

Georg Brabant1, John Cain, Alan Jackson

  • 1Department of Endocrinology, The Christie, Manchester Academic Health Science Centre, Wilmslow Road, Manchester M20 4BX, UK. georg.brabant@manchester.ac.uk

Trends in Endocrinology and Metabolism: TEM
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

Hormones significantly impact the central nervous system (CNS). Advanced imaging techniques like magnetic resonance imaging (MRI) now allow detailed human studies of these hormone effects on brain structure and function.

More Related Videos

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation
09:29

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation

Published on: August 4, 2023

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
10:16

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

Published on: March 12, 2019

Related Experiment Videos

Last Updated: Jun 2, 2026

Ex Vivo Calcium Imaging for Visualizing Brain Responses to Endocrine Signaling in Drosophila
06:49

Ex Vivo Calcium Imaging for Visualizing Brain Responses to Endocrine Signaling in Drosophila

Published on: June 2, 2018

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation
09:29

Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation

Published on: August 4, 2023

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
10:16

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

Published on: March 12, 2019

Area of Science:

  • Neuroendocrinology
  • Neuroimaging

Background:

  • Hormones exert profound effects on central nervous system (CNS) development, maturation, and function.
  • Translating animal model findings to humans requires robust in vivo human study methods.

Purpose of the Study:

  • To review current neuroimaging techniques for studying hormone effects on the human CNS.
  • To highlight recent advancements in magnetic resonance imaging (MRI) for this field.
  • To discuss the potential of these techniques for advancing endocrinology research.

Main Methods:

  • Magnetic resonance imaging (MRI) for detailed in vivo studies of cerebral structure and function.
  • Positron emission tomography (PET) for in vivo human brain studies.
  • Measurement of subtle cerebral structural differences, regional brain activation, and blood flow changes.

Main Results:

  • Recent developments in MRI and PET enable detailed in vivo human studies of hormone effects on the CNS.
  • Advanced techniques allow measurement of physiological biomarkers, facilitating translation from animal models.
  • Current studies demonstrate the utility of these imaging modalities in endocrinology.

Conclusions:

  • Neuroimaging techniques, particularly MRI, are crucial for understanding hormone-CNS interactions in humans.
  • These methods bridge the gap between animal research and human physiology.
  • An emerging field in endocrinology is supported by these advanced imaging capabilities.