Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>APOL1</i> Variants, AKI, and Progression to Kidney Failure in People of African Ancestry Living with HIV.

Kidney international reports·2026
Same author

Systemic Immune-Inflammatory Markers for Predicting Infarct Volume and Mortality in Patients with Acute Ischemic Stroke: A Retrospective Cohort Study.

Journal of clinical medicine·2026
Same author

A Contrastive Learning Framework for Efficient Viral Escape Prediction.

IEEE transactions on computational biology and bioinformatics·2026
Same author

HLA class I signal peptide variation predicts strength of NKG2A<sup>+</sup> NK cell response to missing-self and risk of human disease.

Nature immunology·2026
Same author

Erratum to "Plasma Proteomic Markers of Interleukin-1β Pathway Associated with Incident Age-Related Macular Degeneration in Persons with AIDS" [Ophthalmol Sci. 2025;5:100794].

Ophthalmology science·2026
Same author

Uric Acid Trajectories and CKD Progression in the African American Study of Kidney Disease and Hypertension.

Kidney international reports·2025
Same journal

NET-inducing ability of Cutibacterium acnes clinical isolates is associated with pathogenicity in acne vulgaris.

The Journal of infectious diseases·2026
Same journal

Optimizing the Use of Proviral DNA HIV Drug Resistance Testing: Clinical Applications and Cautions.

The Journal of infectious diseases·2026
Same journal

Monitoring HLA-A2-restricted T cell responses and BCLA-specific serostatus during human latent Toxoplasma gondii infection suggests the implication of CD8+ T cells in parasite containment.

The Journal of infectious diseases·2026
Same journal

Cryptosporidiosis in Ptients with Inborn Errors of Immunity: Retrospective cohort study of the French National Reference Center (CEREDIH).

The Journal of infectious diseases·2026
Same journal

Type 3 fimbrial regulation underpins anti-MrkA immunotherapeutic efficacy in experimental Klebsiella pneumoniae infection.

The Journal of infectious diseases·2026
Same journal

Rationalising heterogeneity in Staphylococcus aureus bacteraemia: current progress and future goals.

The Journal of infectious diseases·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Determining 3'-Termini and Sequences of Nascent Single-Stranded Viral DNA Molecules during HIV-1 Reverse Transcription in Infected Cells
13:07

Determining 3'-Termini and Sequences of Nascent Single-Stranded Viral DNA Molecules during HIV-1 Reverse Transcription in Infected Cells

Published on: January 30, 2019

Genome-wide association study implicates PARD3B-based AIDS restriction.

Jennifer L Troyer1, George W Nelson, James A Lautenberger

  • 1Laboratory of Genomic Diversity, SAIC-Frederick, Inc., Frederick, MD 21702, USA. troyerj@mail.nih.gov

The Journal of Infectious Diseases
|April 20, 2011
PubMed
Summary
This summary is machine-generated.

Host genetics influence human immunodeficiency virus (HIV) and AIDS progression. A genome-wide study identified PARD3B gene variants associated with slower AIDS progression, revealing a new genetic pathway affecting disease dynamics.

More Related Videos

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
10:18

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing

Published on: October 16, 2018

Related Experiment Videos

Last Updated: Jun 2, 2026

Determining 3'-Termini and Sequences of Nascent Single-Stranded Viral DNA Molecules during HIV-1 Reverse Transcription in Infected Cells
13:07

Determining 3'-Termini and Sequences of Nascent Single-Stranded Viral DNA Molecules during HIV-1 Reverse Transcription in Infected Cells

Published on: January 30, 2019

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
10:18

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing

Published on: October 16, 2018

Area of Science:

  • Genetics
  • Immunology
  • Virology

Background:

  • Host genetic variations significantly impact human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) progression.
  • Previous studies highlight the role of host genetics in HIV/AIDS pathogenesis.

Purpose of the Study:

  • To identify host genetic factors associated with the rate of AIDS progression.
  • To conduct a genome-wide association study (GWAS) in well-characterized HIV/AIDS cohorts.

Main Methods:

  • A GWAS was performed on European American HIV seroconverters (n=755).
  • Over 700,000 single-nucleotide polymorphisms (SNPs) were analyzed for association with AIDS progression using Cox proportional hazards regression.
  • Statistical correction for multiple testing was applied.

Main Results:

  • Single-nucleotide polymorphisms (SNPs) in the PARD3B gene were associated with slower AIDS progression.
  • A specific SNP, rs11884476, reached genome-wide significance, explaining 4.52% of the variance in AIDS progression.
  • A PARD3B haplotype defined by nine top SNPs also showed significant association with slower progression. Altered PARD3B splicing was observed in relation to SNP rs10185378, which was protective against AIDS progression in European cohorts.

Conclusions:

  • The PARD3B gene plays a role in modulating the rate of AIDS progression.
  • These findings suggest an unexpected genetic pathway influencing the dynamics of HIV/AIDS.
  • Further research into PARD3B's role in HIV pathogenesis is warranted.