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Updated: Jun 2, 2026
08:05
Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
[Medications. A rare cause for leg ulcers].
1Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Deutschland. joachim.dissemond@uk-essen.de
Summary
Drug-induced leg ulcers are a recognized complication, with hydroxyurea being a notable cause. Recognizing medication
Area of Science:
- Pharmacology and Dermatology
- Investigating drug-induced adverse events
- Pathogenesis of leg ulcers
Context:
- A growing body of evidence links certain medications to the development of leg ulcers.
- The precise etiological mechanisms, including allergic and toxic pathways, are under investigation.
- Establishing a definitive causal relationship between drug intake and leg ulcer occurrence can be challenging.
Purpose:
- To review the association between systemic medications and the onset of leg ulcers.
- To highlight specific drugs, such as hydroxyurea, with a significant reported incidence of causing leg ulcers.
- To emphasize the importance of considering medication as a potential factor in diagnosing and managing leg ulcers.
Summary:
- Numerous systemic drugs can precipitate leg ulcers through direct or indirect mechanisms, often involving vasculitis or vasculopathies.
- While causality is often inferred from case reports and temporal association, hydroxyurea stands out with over 100 documented cases and characteristic ulcer morphology.
- Diagnosis frequently involves excluding other causes and noting the timing of drug initiation relative to ulcer development.
Impact:
- Increased clinical awareness of drug-induced leg ulcers can improve diagnostic accuracy.
- Identifying causative medications allows for timely adjustments to treatment plans, potentially preventing recurrence.
- This understanding contributes to safer prescribing practices and better patient outcomes in dermatology and internal medicine.
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