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Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

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Related Experiment Video

Updated: Jun 2, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

[Impulse control disorders in Parkinson's disease].

O A Van den Heuvel1, Y D Van der Werf, H J Groenewegen

  • 1Afdeling Psychiatrie, Psychiatrisch Consultatieve Dienst, VU Medisch Centrum, Amsterdam. oa.vandenheuvel@vumc.nl

Tijdschrift Voor Psychiatrie
|April 21, 2011
PubMed
Summary

Impulse control disorders are common in Parkinson's disease, affecting 5-10% of patients, often linked to dopaminergic medication. Early recognition and collaboration between neurologists and psychiatrists are crucial for effective treatment.

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Last Updated: Jun 2, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurology

Context:

  • Parkinson's disease presents with motor symptoms (bradykinesia, rigidity, tremor) and non-motor symptoms.
  • Impulse control disorders (ICDs) are significant non-motor symptoms in Parkinson's disease.
  • ICDs include pathological gambling, hypersexuality, compulsive buying, binge eating, punding, and dopamine dependency.

Purpose:

  • To elucidate the clinical presentation of ICDs in Parkinson's disease.
  • To identify risk factors associated with ICDs in Parkinson's disease.
  • To explore treatment strategies and pathophysiological mechanisms of ICDs in Parkinson's disease.

Summary:

  • Impulse control disorders affect 5-10% of Parkinson's disease patients, often coinciding with dopaminergic therapy.
  • These disorders can lead to substantial social, relational, and financial consequences.
  • Phenomenological overlap exists between ICDs in Parkinson's disease and other disorders in the impulsive-compulsive spectrum, including obsessive-compulsive and addiction disorders.

Impact:

  • Early identification of ICDs in Parkinson's disease is critical.
  • Collaboration between neurologists and psychiatrists is essential for accurate diagnosis and optimal management.
  • Shared pathophysiological mechanisms involving frontal-striatal circuitry imbalances may underlie these overlapping disorders.