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Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...

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Related Experiment Video

Updated: Jun 2, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Emerging patterns of epigenomic variation.

Aleksandar Milosavljevic1

  • 1Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX 77030, USA. amilosav@bcm.edu

Trends in Genetics : TIG
|April 22, 2011
PubMed
Summary
This summary is machine-generated.

Epigenome mapping reveals conserved gene regulation across species and parent-of-origin effects in humans. Comparative epigenomics offers insights into cellular differentiation, genetic/environmental influences, and aging.

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Pattern-based Search of Epigenomic Data Using GeNemo
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Pattern-based Search of Epigenomic Data Using GeNemo

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A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
08:04

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

Published on: August 13, 2020

Related Experiment Videos

Last Updated: Jun 2, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
08:04

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

Published on: August 13, 2020

Area of Science:

  • Genomics and Epigenetics
  • Comparative Genomics
  • Population Genetics

Background:

  • Epigenome mapping projects are advancing due to new sequencing technologies.
  • Epigenomic variation is observed across species, populations, and cellular levels.
  • Epigenetic modifications play a crucial role in gene regulation and biological complexity.

Purpose of the Study:

  • To explore the evolutionary conservation of epigenomic patterns across species.
  • To investigate epigenomic variations in human populations, including parent-offspring and twin studies.
  • To understand the role of epigenomes in cellular differentiation, genetic and environmental influences, and aging.

Main Methods:

  • Comparative analysis of methylation profiles across species.
  • Examination of epigenomic changes at population, organismal, and cellular levels.
  • Utilizing new bioinformatic frameworks for comparative epigenome analysis.

Main Results:

  • Evolutionary conservation of gene body methylation patterns identified.
  • Epigenomic changes reflect genomic variant effects and parent-of-origin effects in humans.
  • Epigenomes of diverse cell types provide insights into differentiation; twin studies reveal genetic/environmental influences and aging-associated drift.

Conclusions:

  • Comparative epigenomics is a powerful tool for understanding gene regulation, inheritance, and biological processes.
  • Epigenome maps are becoming accessible to a broad range of biological researchers.
  • Epigenetic insights are crucial for dissecting complex biological phenomena from evolution to aging.