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Updated: Jun 2, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2-(Biphenyl-4-yl-oxy)acetic acid
1Hainan Provincial Key Laboratory of Tropical Pharmaceutical Herb Chemistry, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, People's Republic of China.
Abstract:
In the title compound, C(14)H(12)O(3), the phenyl and benzene rings make a dihedral angle of 47.51 (4)°. In the crystal, mol-ecules are dimerized by double O-H⋯O hydrogen bonds, forming centrosymmetric R(2) (2)(8) ring motifs. The dimers are inter-linked by C-H⋯π inter-actions into zigzag layers.
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