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Related Experiment Video

Updated: Jun 2, 2026

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

[Adipocytes and bone metabolism].

Hironori Waki¹, Toshimasa Yamauchi, Takashi Kadowaki

¹Department of Diabetes and Metabolic Diseases, the University of Tokyo.

Clinical Calcium

|May 3, 2011

Summary

This review explores the link between fat cells (adipocytes) and bone metabolism. It highlights how diabetes drugs may affect bone health, particularly in postmenopausal women.

Area of Science:

Stem cell biology
Metabolic bone disease

Background:

Mesenchymal stem cells differentiate into adipocytes, osteoblasts, and chondrocytes.
Factors influencing the differentiation of these cell types are crucial for understanding tissue homeostasis.
Thiazolidinediones, used for diabetes, have been linked to increased bone fracture risk.

Purpose of the Study:

To review recent research on the interplay between adipocytes and bone metabolism.
To elucidate the mechanisms underlying thiazolidinedione-induced bone alterations.

Main Methods:

Literature review of recent scientific publications.
Analysis of clinical data on thiazolidinedione use and bone health.

Main Results:

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Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

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Last Updated: Jun 2, 2026

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

Adipocyte differentiation is closely linked to osteoblast and chondrocyte development.

Thiazolidinediones may disrupt the balance of bone metabolism, potentially by influencing adipogenesis.

Increased fracture risk in postmenopausal women using these drugs is a significant concern.

Conclusions:

The relationship between fat metabolism and bone health is complex and bidirectional.
Further research is needed to clarify the precise mechanisms by which adipocytes influence bone.
Understanding these interactions is vital for developing safer therapeutic strategies for metabolic and bone diseases.