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Updated: Jun 2, 2026
06:37
Immunolabelling Myofiber Degeneration in Muscle Biopsies
Published on: December 5, 2019
Muscle cell membrane damage by very low serum sodium
Joye Varghese1, Vallath Balakrishnan, Shine Sadasivan
1Department of Gastroenterology, Amrita Institute of Medical Sciences and Research Centre, Cochin, India.
The Pan African Medical Journal
|May 3, 2011
Summary
Severe hyponatremia can trigger rhabdomyolysis, a serious condition causing muscle breakdown. Prompt treatment of low sodium levels is crucial for preserving kidney function and preventing complications.
Area of Science:
- Internal Medicine
- Nephrology
- Endocrinology
Background:
- Hyponatremia, a condition of low sodium levels, can present with non-specific symptoms like fatigue and myalgia.
- Rhabdomyolysis, characterized by muscle breakdown and elevated creatine phosphokinase, is a potential complication of severe hyponatremia.
- Myoglobinuria, resulting from muscle damage, can lead to acute kidney injury.
Purpose of the Study:
- To report a case of hyponatremia-induced rhabdomyolysis.
- To highlight the importance of early diagnosis and prompt management of this condition.
- To emphasize the link between electrolyte imbalances and muscle pathology.
Main Methods:
- A 63-year-old male patient presented with upper gastrointestinal symptoms, fatigue, and myalgia.
- Laboratory investigations revealed severe hyponatremia and elevated creatine phosphokinase.
- Clinical diagnosis of hyponatremia-induced rhabdomyolysis was established following comprehensive workup.
Main Results:
- The patient was diagnosed with severe hyponatremia leading to rhabdomyolysis.
- Prompt correction of hyponatremia was initiated.
- Renal function was preserved, and acute kidney injury secondary to myoglobinuria was successfully avoided.
Conclusions:
- Hyponatremia can precipitate rhabdomyolysis, a potentially life-threatening condition.
- Early recognition and rapid correction of hyponatremia are vital for preventing renal failure.
- This case underscores the significance of considering electrolyte disturbances in patients with unexplained myalgia and elevated muscle enzymes.
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