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Updated: Jun 2, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
14:57

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases

Published on: October 10, 2020

Glutathione S-transferases and cancer (Review)

D Schipper1, M Wagenmans, D Wagener

  • 1UNIV NIJMEGEN HOSP,DEPT GASTROENTEROL,NL-6500 HB NIJMEGEN,NETHERLANDS. UNIV NIJMEGEN HOSP,DEPT MED ONCOL,NL-6500 HB NIJMEGEN,NETHERLANDS.

International Journal of Oncology
|May 3, 2011
PubMed

Insights

Glutathione S-transferases (GSTs) are enzymes crucial for drug metabolism. This review explores their role in anticancer drug resistance and discusses GST pi

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Cytosolic glutathione S-transferases (GSTs) are key enzymes in cellular detoxification pathways.
  • GSTs metabolize endogenous and exogenous compounds, including drugs, toxins, and carcinogens.
  • Emerging evidence suggests GSTs are implicated in cellular resistance mechanisms.

Purpose of the Study:

  • To review the existing literature on the role of glutathione S-transferases in anticancer drug resistance.
  • To discuss the significance of GST pi in the context of carcinogenesis.
  • To evaluate the prognostic value of GST pi.

Main Methods:

  • Comprehensive literature review of studies investigating GSTs and drug resistance.
  • Analysis of research on GST pi in cancer development.
  • Examination of data correlating GST pi expression with patient prognosis.

Main Results:

  • Glutathione S-transferases (GSTs) are increasingly recognized for their involvement in resistance to chemotherapy.
  • GST pi, in particular, shows significant implications in the development of cancer.
  • Expression levels of GST pi may serve as a predictive marker for treatment outcomes.

Conclusions:

  • Glutathione S-transferases play a critical role in mediating resistance to anticancer therapies.
  • GST pi is a significant factor in carcinogenesis and holds potential as a prognostic indicator.
  • Targeting GSTs could offer novel strategies for overcoming drug resistance in cancer treatment.

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