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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The two main cell types that...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

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Collection of Serum- and Feeder-free Mouse Embryonic Stem Cell-conditioned Medium for a Cell-free Approach
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Emerging models and paradigms for stem cell ageing.

D Leanne Jones1, Thomas A Rando

  • 1Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Nature Cell Biology
|May 5, 2011
PubMed
Summary
This summary is machine-generated.

Stem cell function declines with age, impairing tissue repair. Invertebrate models reveal molecular insights into age-related stem cell dysfunction and changes in self-renewal and differentiation.

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Area of Science:

  • Gerontology
  • Stem Cell Biology
  • Molecular Biology

Background:

  • Aging leads to a decline in stem cell function.
  • This dysfunction impacts tissue homeostasis and repair processes.
  • Understanding these changes is crucial for regenerative medicine.

Purpose of the Study:

  • To explore how stem cell function changes with age.
  • To discuss insights from invertebrate models on aging stem cells.
  • To identify molecular pathways of age-related stem cell dysfunction.

Main Methods:

  • Review of emerging invertebrate models.
  • Analysis of molecular pathways in stem cell aging.
  • Comparative study of stem cell function across species.

Main Results:

  • Stem cell self-renewal capacity diminishes with age.
  • Differentiation potential of aged stem cells becomes aberrant.
  • Invertebrate models offer conserved mechanisms of stem cell aging.

Conclusions:

  • Age-related stem cell dysfunction is a conserved process.
  • Invertebrate models are valuable for studying aging stem cells.
  • Targeting these pathways may improve age-related tissue repair.