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Related Concept Videos

DNA Replication02:40

DNA Replication

DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication uses a large number of...
Replication in Prokaryotes02:35

Replication in Prokaryotes

Overview
Replication in Prokaryotes02:35

Replication in Prokaryotes

Overview
Replication in Prokaryotes01:32

Replication in Prokaryotes

DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the single origin of replication (ori) on the cell's circular chromosome. Replication then proceeds around the entire circle of the chromosome in each direction from the two replication forks, resulting in two DNA molecules.
Many Proteins Work Together to Replicate the Chromosome
Replication is coordinated and carried out by a host of specialized...
Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...

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Updated: Jun 2, 2026

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence
06:25

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence

Published on: February 10, 2023

Replication in prevention science.

Jeffrey C Valentine1, Anthony Biglan, Robert F Boruch

  • 1309 College of Education, University of Louisville, Louisville, KY 40205, USA. jeff.valentine@louisville.edu

Prevention Science : the Official Journal of the Society for Prevention Research
|May 5, 2011
PubMed
Summary
This summary is machine-generated.

Replication research in prevention science is crucial for public health. Conducting more systematic replications and using advanced methods to synthesize evidence improves intervention decisions and impact.

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Published on: October 27, 2011

Area of Science:

  • Prevention science
  • Public health research
  • Intervention science

Background:

  • Replication research is fundamental to scientific progress.
  • Prevention science requires robust evidence for effective public health interventions.
  • Current demands often necessitate timely intervention decisions without extensive replication data.

Purpose of the Study:

  • To advocate for increased and improved replication studies in prevention science.
  • To propose strategies for evaluating intervention utility based on existing evidence.
  • To suggest structural changes that foster high-quality replication research.

Main Methods:

  • Literature review and synthesis of existing evidence on intervention effects.
  • Development of strategies for estimating intervention effects from current knowledge.
  • Analysis of structural factors influencing replication research, including incentives and prospective registers.
  • Discussion of methods for integrating replications into program implementation.

Main Results:

  • More systematic replications are needed, utilizing state-of-the-art methods for evidence synthesis.
  • Strategies can guide decisions on intervention adoption by estimating effect sizes and ranges.
  • Incentives and research registers can enhance the quantity and quality of replication studies.
  • Partnerships with decision-makers are vital for successful replication integration.

Conclusions:

  • Enhanced replication research and advanced review methods will strengthen prevention science.
  • Improved understanding of intervention effects supports better public health outcomes.
  • Systematic replication and evidence synthesis are key to advancing public health through prevention science.