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Updated: Jun 2, 2026

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies
Published on: September 1, 2023
Mechanics and dynamics of triglyceride-phospholipid model membranes: Implications for cellular properties and
Kirsi I Pakkanen1, Lars Duelund, Klaus Qvortrup
1MEMPHYS - Center for Biomembrane Physics, Department of Physics and Chemistry, University of Southern Denmark, Odense, Denmark. kipa@nanotech.dtu.dk
Abstract:
We demonstrate here that triolein alters the mechanical properties of phospholipid membranes and induces extraordinary conformational dynamics. Triolein containing membranes exhibit fluctuations up to size range of 100μm and with the help of these are e.g. able to squeeze through narrow passages between neighbouring structures. Triolein-phosphatidylcholine membranes were found to have bending rigidity significantly lower than that of corresponding pure phosphatidylcholine membrane. Moreover, the triolein containing membranes were found to be reluctant to fuse, which is in good accordance with larger lamellar distances observed in the TOPOPC membranes. These findings suggest repulsion between adjacent membranes. We provide a comprehensive discussion on the possible explanations for the observed mechanics and dynamics in the TOPOPC system and on their potential cellular implications.
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