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Symptom and functional outcomes for a 5 year early intervention program for psychoses.
Ross M G Norman1, Rahul Manchanda, Ashok K Malla
1Department of Psychiatry, The University of Western Ontario, Rm. 114A-WMCH Bldg, 392 South Street, London, ON Canada N6A 4G5. rnorman@uwo.ca
Schizophrenia Research
|May 10, 2011
Summary
Specialized early intervention programs (SEI) for psychosis show sustained symptom improvement and enhanced functioning at five years. Longer continuity of care in SEI is linked to ongoing benefits for patients.
Area of Science:
- Psychiatry and Mental Health
- Clinical Psychology
- Neuroscience
Background:
- Controversy exists regarding the long-term benefits of specialized early intervention (SEI) programs for psychotic disorders.
- Recent reports suggest that initial benefits of SEI programs may diminish by five-year follow-up.
- The Prevention and Early Intervention Program for Psychoses (PEPP) offers extended care, with reduced intensity after two years.
Purpose of the Study:
- To examine if outcomes observed at two years in the PEPP program are maintained at five-year follow-up.
- To compare PEPP outcomes with the OPUS project at both two and five-year intervals.
- To assess the impact of longer-term continuity of care within SEI.
Main Methods:
- Longitudinal study examining outcomes of the PEPP program.
- Assessment of symptom improvement and global functioning at two and five-year follow-ups.
- Comparative analysis with data from the OPUS project.
Main Results:
- Symptom improvements achieved between entry and two-year follow-up in PEPP were maintained at five years.
- Further improvement in global functioning was observed between the two and five-year follow-up points.
- PEPP outcomes, compared to OPUS, suggest longer continuity of care in SEI is associated with sustained benefits in positive symptoms and functioning.
Conclusions:
- The PEPP program demonstrates that initial gains in symptom reduction for psychosis can be sustained over five years.
- Extended continuity of care within specialized early intervention programs appears to promote ongoing functional improvements.
- Findings support the value of longer-term, albeit lower-intensity, specialized care in managing psychotic disorders.
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