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Related Experiment Video

Updated: Jun 2, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
09:33

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

Prognostic implication of estramustine-binding protein in astrocytoma.

A Bergenheim1, A Karlsson, A Stahl

  • 1UMEA UNIV HOSP, DEPT ONCOL, S-90185 UMEA, SWEDEN. AKAD SJUKHUSET, DEPT NEUROPATHOL, UPPSALA, SWEDEN.

International Journal of Oncology
|May 10, 2011
PubMed
Summary

Estramustine-binding protein (EMBP) expression correlates with astrocytoma malignancy. High EMBP levels indicate shorter patient survival, suggesting its potential as a prognostic marker in astrocytoma treatment.

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Area of Science:

  • Neuro-oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Estramustine-binding protein (EMBP) is a glycoprotein found in astrocytoma cytoplasm.
  • EMBP expression correlates with neoplastic transformation in astrocytoma.
  • EMBP is implicated in estramustine binding within astrocytoma tumors.

Purpose of the Study:

  • To evaluate estramustine-binding protein (EMBP) expression in astrocytoma tissues.
  • To investigate the correlation between EMBP levels and astrocytoma grade.
  • To assess the prognostic value of EMBP expression for patient survival.

Main Methods:

  • Immunohistochemistry was used to assess EMBP expression and staining patterns.
  • Radioimmunoassay quantified EMBP levels in tumor tissue samples.

Related Experiment Videos

Last Updated: Jun 2, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
09:33

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

  • Patient survival data was analyzed in relation to EMBP expression levels.

    • Main Results:

    • EMBP expression (staining intensity and cell count) increased with astrocytoma grade.
    • EMBP levels ranged from 1.3-6.2 ng/g, with higher concentrations in grades III-IV.
    • High EMBP expression was associated with shorter patient survival, while low expression did not guarantee a favorable outcome.

    Conclusions:

    • EMBP expression is a potential predictive marker for survival in astrocytoma patients.
    • EMBP levels may be particularly relevant when estramustine is part of the treatment strategy.
    • Further extensive research is required to confirm these findings and establish definitive conclusions.