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Related Concept Videos

Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis01:18

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell eating"). Pinocytosis is...
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...

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Related Experiment Video

Updated: Jun 2, 2026

Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy
08:17

Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy

Published on: August 16, 2021

Vesicular traffic in cell navigation.

Kathleen Zylbersztejn1, Thierry Galli

  • 1'Membrane Traffic in Neuronal & Epithelial Morphogenesis', INSERM ERL U950, Paris, France.

The FEBS Journal
|May 11, 2011
PubMed
Summary
This summary is machine-generated.

Soluble N-ethylmaleimide-sensitive fusion attachment protein (SNAP) receptors (SNAREs) are crucial for cell navigation by mediating membrane fusion and intracellular trafficking. This review highlights their essential roles and potential therapeutic applications.

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Last Updated: Jun 2, 2026

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Visualizing Intracellular SNARE Trafficking by Fluorescence Lifetime Imaging Microscopy
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Visualizing Intracellular SNARE Trafficking by Fluorescence Lifetime Imaging Microscopy

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Neuroscience

Background:

  • Cell navigation is vital for organism development and function.
  • Membrane trafficking is increasingly recognized as a key player in cell movement.
  • Soluble N-ethylmaleimide-sensitive fusion attachment protein (SNAP) receptors (SNAREs) mediate membrane fusion.

Purpose of the Study:

  • To review the role of SNAREs in cell navigation.
  • To discuss specific SNARE proteins involved in this process.
  • To explore potential therapeutic implications of SNARE research.

Main Methods:

  • Literature review of recent research on SNAREs and cell navigation.
  • Analysis of the functions of specific vesicular- and target-SNAREs.
  • Discussion of the role of endosomal SNAREs.

Main Results:

  • SNAREs are essential for intracellular vesicular trafficking, a process critical for cell navigation.
  • Specific SNAREs, including VAMPs, Vti1a/b, SNAP23/25, and Syntaxins 1, 3, 6, 13, play significant roles.
  • Endosomal SNAREs are particularly important for guiding cell movement.

Conclusions:

  • Endosomal SNAREs are critical for cell navigation, opening new research avenues.
  • Understanding SNARE function in cell navigation may lead to therapeutic strategies.
  • Some SNAREs are targets of clostridial neurotoxins, suggesting potential pharmacological applications.