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Updated: Jun 2, 2026
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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Randomized controlled trial on lateral augmentation using two collagen membranes: morphometric results on mineralized
Anton Friedmann1, Kirsten Gissel, Mouaz Soudan
1Department of Periodontology, School of Dentistry, Faculty of Health, University of Witten, Witten, Germany. anton.friedmann@uni-wh.de
Journal of Clinical Periodontology
|May 12, 2011
Summary
Ribose cross-linked collagen membranes (RCLM) enhanced bone regeneration in alveolar ridge augmentation. This study found RCLMs significantly increased new bone formation compared to non-cross-linked membranes, even with healing complications.
Area of Science:
- Dental Implantology
- Periodontology
- Biomaterials Science
Background:
- Guided bone regeneration is crucial for alveolar bone augmentation before dental implant placement.
- Deficient alveolar ridges and exposed implant surfaces require effective bone grafting solutions.
Purpose of the Study:
- To compare the efficacy of ribose cross-linked collagen membranes (RCLM) versus non-cross-linked membranes in one-stage alveolar bone augmentation.
- To assess the impact of membrane type on dimensional changes in bone margins at the crestal level.
Main Methods:
- A randomized pilot study involving 37 patients undergoing one-stage augmentation of bone dehiscences.
- Seventeen patients received biphasic calcium phosphate with RCLM, while 20 controls received non-cross-linked membranes.
- Morphometric assessment of alveolar ridge alterations was performed 6 months post-surgery.
Main Results:
- Significant increases in hard newly mineralized tissue were observed in the RCLM group compared to controls.
- Lateral bone gain was 1.8 mm (RCLM) vs. 0.7 mm (controls; p=.046), and vertical gain was 1.1 mm (RCLM) vs. 0.2 mm (controls; p=.035).
- Soft tissue dehiscencies occurred more frequently in the RCLM group (70.5%) than controls (55%).
Conclusions:
- Both membrane types facilitated bone augmentation, but RCLM demonstrated superior support for mineralization and remodeling.
- RCLM proved effective even in compromised healing sites, as evidenced by morphometric outcomes.
- The study highlights RCLM as a promising biomaterial for enhancing guided bone regeneration.
