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Characteristics and prognosis of patients requiring valve surgery during active infective endocarditis

Georges Fayad1, Guillaume Leroy, Patrick Devos

  • 1Pôle de Chirurgie Cardiovasculaire, CHRU de Lille and Hôpital Cardiologique, CHRU de Lille, France. g.fayad@sfr.fr

The Journal of Heart Valve Disease
|May 13, 2011
PubMed

Insights

Surgery for active infective endocarditis (IE) carries a high operative mortality rate. Prosthetic valve endocarditis (PVE) independently predicts worse outcomes, emphasizing the need for adequate antimicrobial therapy.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Infectious Diseases

Background:

  • Active infective endocarditis (IE) often necessitates urgent valve surgery.
  • Understanding operative mortality and associated factors is crucial for patient management.

Purpose of the Study:

  • To characterize patients undergoing valve surgery for active IE.
  • To identify factors influencing operative mortality in this high-risk group.

Main Methods:

  • Retrospective analysis of 141 patients with active IE undergoing cardiac operations.
  • Data collected on patient demographics, valve involvement, pathogens, and outcomes.
  • Modified Duke criteria used for IE classification; active IE defined by surgery before antimicrobial completion.

Main Results:

  • 16% operative mortality observed in the cohort.
  • Native valve endocarditis was most common (87%).
  • Prosthetic valve endocarditis (PVE) was an independent predictor of operative mortality (aOR=4.16).

Conclusions:

  • Valve surgery for active IE is associated with significant operative mortality.
  • PVE portends a poorer prognosis.
  • Adequate antimicrobial therapy may improve outcomes in patients with active IE.
Abstract

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