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Hospitalizations before and after initiation of chronic hemodialysis
Hussein Kassam1, Yijuan Sun, Muniru Adeniyi
1Department of Surgery, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Insights
Hospitalization rates and lengths significantly increased after patients started chronic hemodialysis (HD). This highlights the need to study HD-specific factors to reduce patient morbidity.
Area of Science:
- Nephrology
- Internal Medicine
- Public Health
Background:
- Patients on chronic hemodialysis (HD) experience high hospitalization rates.
- Understanding how initiating HD impacts hospitalization is crucial for patient care.
Purpose of the Study:
- To investigate the changes in hospitalization rate and length following the initiation of chronic hemodialysis.
- To compare hospitalization patterns in the pre-HD period versus the HD period.
Main Methods:
- A 15-year retrospective analysis of hospitalizations in 392 patients undergoing HD at a single hospital.
- Comparison of annual hospitalization rates (admissions/patient-year) and lengths (days/patient-year) between the pre-HD and HD periods.
Main Results:
- Hospitalization rates increased from 0.557 (pre-HD) to 2.198 (HD) admissions/patient-year (P<0.001).
- Hospitalization lengths increased from 4.63 (pre-HD) to 28.07 (HD) days/patient-year (P<0.001).
- Increases were observed across various conditions, including cardiac disease, infections, and HD-specific issues, with diabetics showing higher rates.
Conclusions:
- Initiation of chronic hemodialysis is associated with a significant rise in both the rate and length of hospitalizations.
- Further research into HD-specific factors is necessary to mitigate increased patient morbidity.
Abstract:
Hospitalization rate is high in patients on chronic hemodialysis (HD). We investigated whether initiation of HD changes the rate and length of hospitalization. We analyzed hospitalizations in HD patients in one hospital over 15 years. We compared annual rate and length of hospitalizations, both presented as mean (95% confidence interval [CI]) between the pre-HD and HD period. Three hundred ninety-two patients, 98% men, 59% diabetic, and 66.3 ± 11.2 years old at the onset of HD, had 1016 hospitalizations in the pre-HD period (60.0 ± 42.9 months) and 1627 hospitalizations in the HD period (32.5 ± 25.9 months). Higher values were found in the HD than the pre-HD period for rate, (pre-HD 0.557 [95% CI 0.473-0.611], HD 2.198 [95% CI 1.997-2.399] admissions/[patient-year], P<0.001) and length (pre-HD 4.63 [95% CI 3.71-5.55], HD 28.07 [95% CI 23.55-32.59] days/patient-year], P<0.001) of hospitalizations for all causes, cardiac disease, infections, vascular access, peripheral vascular disease, metabolic disturbances, gastrointestinal diseases, and miscellaneous conditions, mainly respiratory illness and malignancy. Similar differences were found when we compared the year before and the year after the start of HD. Diabetics had higher all cause rate and length of hospitalizations than non-diabetics in the pre-HD and HD periods. The rate and length of hospitalizations was higher in the HD than the pre-HD period for both HD-specific conditions and conditions encountered in both HD and general populations. Study of factors specific to HD that may affect these conditions should constitute the first step toward improving the morbidity of patients on HD.
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