Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormonal Regulation01:40

Hormonal Regulation

37.6K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
37.6K
Feedback Loops01:01

Feedback Loops

43.9K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
43.9K
Hormonal Regulation01:33

Hormonal Regulation

30.4K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
30.4K
Regulation of Metabolism01:19

Regulation of Metabolism

9.1K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.1K
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

6.5K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
6.5K
Regulation of Food Intake01:30

Regulation of Food Intake

2.8K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of the Surface Structure on the Water Transport Behavior in PEMFC Carbon Fiber Papers.

ACS omega·2022
Same author

Advances in Ophthalmic Optogenetics: Approaches and Applications.

Biomolecules·2022
Same author

A Scoping Review of Drug Epidemic Models.

International journal of environmental research and public health·2022
Same author

Evaluation of reconstructed auricles by convolutional neural networks.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2022
Same author

Facial expression recognition based on deep learning.

Computer methods and programs in biomedicine·2022
Same author

Glucagon-Like Peptide-1 Receptor Regulates Macrophage Migration in Monosodium Urate-Induced Peritoneal Inflammation.

Frontiers in immunology·2022
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

17.2K

A hormone-dependent module regulating energy balance.

Biao Wang1, Noel Moya, Sherry Niessen

  • 1Peptide Biology Laboratories, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.

Cell
|May 14, 2011
PubMed
Summary
This summary is machine-generated.

Scientists discovered a new hormone-regulated pathway involving SIK3 and HDAC4 that controls energy balance in flies during fasting. This pathway works alongside the SIRT1 pathway to manage fat and glucose metabolism.

More Related Videos

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
06:57

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Published on: November 11, 2021

5.3K
Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

2.8K

Related Experiment Videos

Last Updated: May 4, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

17.2K
Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
06:57

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Published on: November 11, 2021

5.3K
Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

2.8K

Area of Science:

  • Metabolic regulation
  • Molecular endocrinology
  • Drosophila genetics

Background:

  • Metazoans shift to fat burning during fasting to maintain energy balance.
  • SIRT1 deacetylates FOXO to promote catabolic gene expression under stress and nutrient deprivation.
  • Hormonal regulation of FOXO deacetylation is not fully understood.

Purpose of the Study:

  • To identify the mechanisms by which hormonal signals regulate FOXO deacetylation.
  • To elucidate the role of a hormone-dependent module in energy balance.

Main Methods:

  • Utilized Drosophila melanogaster as a model organism.
  • Investigated the roles of Ser/Thr kinase SIK3 and class IIa deacetylase HDAC4.
  • Analyzed FOXO activity, phosphorylation, and subcellular localization.
  • Assessed fly starvation sensitivity and lipid accumulation.

Main Results:

  • Identified SIK3 and HDAC4 as a hormone-dependent module regulating FOXO activity.
  • SIK3 phosphorylates and sequesters HDAC4 in the cytoplasm during feeding (insulin-stimulated).
  • SIK3 inactivation during fasting leads to HDAC4 nuclear translocation and FOXO deacetylation.
  • SIK3 mutant flies exhibit starvation sensitivity due to FOXO-dependent lipolysis.
  • Reducing HDAC4 expression restored lipid accumulation in SIK3 mutant flies.

Conclusions:

  • A novel hormone-regulated pathway involving SIK3 and HDAC4 controls FOXO activity and energy balance.
  • This pathway functions in parallel with the SIRT1 pathway.
  • The findings provide insights into metabolic adaptation during fasting.