Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cerebral Hemispheres01:05

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours.

Nature·2026
Same author

Donafenib suppresses glioblastoma progression: potential enhancement of therapeutic response in TMZ-resistant models.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

Acquired genetic and cell-state changes in IDH-mutant glioma progression.

Nature·2026
Same author

Combinatory Effects of Indoximod and Melatonin Alleviate Myeloid Derived Suppressor Cells Driven Triple Negative Breast Cancer Progression and Metastasis.

Journal of pineal research·2026
Same author

Human claustrum neurons encode uncertainty and prediction errors during aversive learning.

bioRxiv : the preprint server for biology·2026
Same author

A guide to using embedded ethics in human stem-cell-based embryo model research.

Nature cell biology·2026

Related Experiment Video

Updated: Jun 2, 2026

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
07:14

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

Published on: January 16, 2026

CCM2 expression during prenatal development and adult human neocortex.

Gamze Tanriover1, Berna Sozen, Murat Gunel

  • 1Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, 07070, Antalya, Turkey. gamzetanriover@yahoo.com

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
|May 17, 2011
PubMed
Summary

Cerebral cavernous malformation (CCM) involves abnormal brain blood vessels. This study reveals the CCM2 protein

More Related Videos

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Related Experiment Videos

Last Updated: Jun 2, 2026

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
07:14

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

Published on: January 16, 2026

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Cerebral cavernous malformation (CCM) is a common central nervous system vascular malformation affecting approximately 1 in 200 individuals.
  • CCM lesions are characterized by dilated vascular channels with a single endothelial cell layer.
  • Genetic studies have identified three loci (CCM1, CCM2, CCM3) associated with CCM, with causative genes now identified.

Purpose of the Study:

  • To investigate the expression patterns of the CCM2 protein in the developing and adult human neocortex.
  • To explore the potential role of CCM2 in blood vessel formation, vasculogenesis, and angiogenesis during human brain development.

Main Methods:

  • Immunohistochemistry was employed to analyze CCM2 protein expression.
  • Western blot analysis was utilized to quantify CCM2 protein levels.
  • Human prenatal and adult neocortex tissues were examined.

Main Results:

  • CCM2 protein was detected in vascular endothelium and neuroglial precursor cells during prenatal development.
  • In the adult neocortex, CCM2 was observed in arterial endothelium, neurons, and some glial cells.
  • This study provides the first description of CCM2 expression in the developing human neocortex.

Conclusions:

  • The expression patterns of CCM2 suggest a potential role in arterial identity and blood vessel development.
  • CCM2 may play a significant role in human brain vasculogenesis and angiogenesis.
  • Further research into CCM2's function could offer new insights into CCM pathophysiology.