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Related Concept Videos

The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Accessory Structures of the Skin: Sweat Glands01:20

Accessory Structures of the Skin: Sweat Glands

Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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Related Experiment Video

Updated: Jun 2, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Skin moisturization mechanisms: new data.

F Bonté1

  • 1LVMH Recherche, Saint-Jean-de-Braye, France. fredericbonte@research.lvmh-pc.com

Annales Pharmaceutiques Francaises
|May 17, 2011
PubMed
Summary
This summary is machine-generated.

Healthy skin moisturization is key for its protective barrier function and appearance. Maintaining skin hydration involves natural moisturizing factors, hyaluronic acid, and aquaporins, crucial for anti-aging and environmental protection.

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Measuring and Modeling Contractile Drying in Human Stratum Corneum
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Related Experiment Videos

Last Updated: Jun 2, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
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Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

Measuring and Modeling Contractile Drying in Human Stratum Corneum
08:00

Measuring and Modeling Contractile Drying in Human Stratum Corneum

Published on: March 1, 2017

Area of Science:

  • Dermatology
  • Skin Biology
  • Biochemistry

Background:

  • The skin's primary role is protection against external factors and water loss.
  • The stratum corneum, composed of corneocytes and lipids, forms the skin barrier.
  • Skin moisturization is vital for appearance, barrier function, and anti-aging.

Purpose of the Study:

  • To explore the mechanisms of skin moisturization.
  • To understand the role of aquaporins and other factors in maintaining skin hydration.
  • To highlight the importance of skin moisture in protecting against environmental damage.

Main Methods:

  • Review of current scientific literature on skin barrier function and moisturization.
  • Analysis of the role of natural moisturizing factors, hyaluronic acid, and aquaporins.
  • Examination of the influence of water and pH on epidermal enzymes and lipid synthesis.

Main Results:

  • Skin hydration relies on natural moisturizing factors, hyaluronic acid, and regulated water transport via aquaporins.
  • Corneodesmosomes and tight junctions contribute to skin moisturization.
  • Water and pH are critical for epidermal enzyme activity, desquamation, and lipid synthesis.

Conclusions:

  • Effective skin moisturization is essential for maintaining skin barrier integrity and appearance.
  • Aquaporins play a significant role in epidermal water transport and overall skin hydration.
  • Adequate skin moisture enhances protection against irritants and environmental stressors.