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Flow through a mechanical distraction enterogenesis device: a pilot test.

Eiichi A Miyasaka1, Manabu Okawada, Richard Herman

  • 1Section of Pediatric Surgery, Department of Surgery and the C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan, USA.

The Journal of Surgical Research
|May 17, 2011
PubMed
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This study tested a prototype intestinal coupling device, finding it allows simulated enteric contents (SEC) to flow through pig and human jejunum without obstruction. Even with a 75% reduction in flow area, the device maintained patency, suggesting viability for in-continuity device placement.

Area of Science:

  • Gastroenterology
  • Biomedical Engineering
  • Surgical Devices

Background:

  • Testing the coupling mechanism of a novel intraluminal distraction enterogenesis device.
  • Assessing the device's capacity for flow-through of simulated enteric contents (SEC).
  • Evaluating performance in both porcine and human jejunal segments.

Purpose of the Study:

  • To evaluate the patency of a prototype intestinal coupling adaptor for an enterogenesis device.
  • To determine if the coupling adaptor obstructs the flow of simulated enteric contents (SEC).
  • To assess the device's functionality under reduced flow-through area conditions.

Main Methods:

  • Simulated enteric contents (SEC) prepared using 80% corn syrup.
  • Ten-cm segments of pig and human jejunum were used with a 2.2 cm spoke-shaped coupling adaptor.

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  • SEC was pumped at 0.083 mL/s; time to first passage, 10 mL, and 20 mL elution were recorded.

    • Main Results:

    • No significant difference in mean time to first SEC drop between pig (155 ± 38 s) and human (149 ± 22 s) jejunum.
    • Mean flow rates were comparable: 0.094 mL/s (pig) and 0.084 mL/s (human).
    • A 75% reduction in flow-through area in pig jejunum slightly increased time to first drop but did not alter elution rate.

    Conclusions:

    • The prototype intestinal coupling adaptor permits SEC flow-through at physiologic pressure levels.
    • The device demonstrated patency even with a significant (75%) reduction in flow-through area.
    • This coupling approach is a viable method for in-continuity device placement without impeding enteric flow.