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Updated: Jun 2, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
Nevus depigmentosus treated by melanocyte-keratinocyte transplantation
Sanjeev V Mulekar1, Ahmed Al Issa, Abdullah Al Eisa
1National Center for Vitiligo and Psoriasis, Olaya District, Tahlia Street, Riyadh, Kingdom of Saudi Arabia.
Background:
Nevus depigmentosus is a congenital, nonprogressive hypopigmented disorder. Various therapeutic methods have been attempted to repigment nevus with variable results.
Objective:
The objective of this study is to report our experience of treatment of nevus depigmentosus with a combination of noncultured melanocyte-keratinocyte transplantation (MKTP) and excimer laser sessions.
Materials And Methods:
Six patients (male 1, female 5) of nevus depigmentosus were treated with a combination of noncultured melanocyte-keratinocyte transplantation and excimer laser. One patient was lost to follow-up. Remaining five patients were observed for a period ranging from 7 to 30 months.
Results:
Two patients responded poorly to MKTP. The remaining three patients responded with repigmentation ranging from 80% to 100% but the quality of repigmentation was unsatisfactory in two of them.
Conclusion:
Though repigmentation of nevus depigmentosus is possible by grafting techniques, the results are inconsistent and recurrence is possible.
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