Self-similarity in NMR Spectra: An Application in Assessing the Level of Cysteine
Related Experiment Video
Updated: Jun 2, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Yoon Young Jung1, Youngja Park, Dean P Jones
1Ewha Womans University.
Abstract:
High resolution of NMR spectroscopic data of biosamples are a rich source of information on the metabolic response to physiological variation or pathological events. There are many advantages of NMR techniques such as the sample preparation is fast, simple and non-invasive. Statistical analysis of NMR spectra usually focuses on differential expression of large resonance intensity corresponding to abundant metabolites and involves several data preprocessing steps. In this paper we estimate functional components of spectra and test their significance using multiscale techniques. We also explore scaling in NMR spectra and use the systematic variability of scaling descriptors to predict the level of cysteine, an important precursor of glutathione, a control antioxidant in human body. This is motivated by high cost (in time and resources) of traditional methods for assessing cysteine level by high performance liquid chromatograph (HPLC).
More Related Videos
Related Concept Videos
2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)
2D NMR: Homonuclear Correlation Spectroscopy (COSY)
¹H NMR: Interpreting Distorted and Overlapping Signals
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are slanted or...
¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons
NMR Spectroscopy Of Amines
¹H NMR Signal Integration: Overview

