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A role of matrix metalloproteinases produced by glioma-cells

H Maruiwa1, Y Sasaguri, M Shigemori

  • 1UNIV OCCUPAT & ENVIRONM HLTH,DEPT PATHOL,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN. KURUME UNIV,SCH MED,DEPT PATHOL,KURUME 830,JAPAN. KURUME UNIV,SCH MED,DEPT NEUROSURG,KURUME 830,JAPAN.

International Journal of Oncology
|May 17, 2011
PubMed

Insights

Matrix metalloproteinases (MMPs) are secreted by glioma cells. Their secretion correlates with glioma tumorigenicity, suggesting a role in tumor development.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Matrix metalloproteinases (MMPs) are enzymes implicated in extracellular matrix degradation.
  • Gliomas are primary brain tumors with varying degrees of malignancy.
  • The role of MMPs in glioma pathogenesis remains an area of active investigation.

Purpose of the Study:

  • To investigate the secretion of MMPs in human glioma cell lines.
  • To determine the correlation between MMP secretion and glioma cell tumorigenicity.
  • To identify specific MMPs involved in glioma progression.

Main Methods:

  • Analysis of MMP secretion in eight glioma cell lines.
  • Immunoblot analysis using antisera against human MMPs.
  • Assessment of in vitro tumorigenetic potential.

Main Results:

  • Four types of MMPs (MMP-1, MMP-2, MMP-3, MMP-9) were detected in glioma cells.
  • MMP-2 was consistently found in high-grade gliomas.
  • Tumorigenic potential correlated with the level of MMP secretion.

Conclusions:

  • MMPs are secreted by glioma cells and play a significant role in their growth and development.
  • MMP-2 is a key enzyme in high-grade gliomas.
  • Targeting MMPs may offer a therapeutic strategy for gliomas.

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