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Related Experiment Video

Updated: Jun 2, 2026

Single-cell Microinjection for Cell Communication Analysis
09:59

Single-cell Microinjection for Cell Communication Analysis

Published on: February 26, 2017

A universal piezo-driven ultrasonic cell microinjection system.

Haibo Huang1, James K Mills, Cong Lu

  • 1Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada. hbhuang@mie.utoronto.ca

Biomedical Microdevices
|May 17, 2011
PubMed
Summary
This summary is machine-generated.

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A new piezo-driven cell injector reduces mercury toxicity and cell damage for improved microinjection in biotechnology. This automated system enhances precision and survival rates in cell injection procedures.

Area of Science:

  • Biotechnology and bioengineering
  • Cell biology and microfluidics

Background:

  • Advancements in biotechnology necessitate high-precision automated microinjection equipment.
  • Current piezo-driven injectors using mercury have limitations including toxicity and cell membrane damage.

Purpose of the Study:

  • To develop a novel automated cell injection system for suspended cells.
  • To design a piezo-driven injector that minimizes harmful lateral tip oscillations and mercury use.

Main Methods:

  • A new piezo-driven cell injector design with the actuator relocated to the pipette tip.
  • Analysis of the piezo-driven cell injection process using ultrasonic vibration micro-dissection (UVM) theory.
  • Preliminary experiments involving microinjection into zebrafish embryos.

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Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons
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Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons

Published on: December 10, 2009

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Last Updated: Jun 2, 2026

Single-cell Microinjection for Cell Communication Analysis
09:59

Single-cell Microinjection for Cell Communication Analysis

Published on: February 26, 2017

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons
13:39

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons

Published on: December 10, 2009

Main Results:

  • The new design substantially reduced lateral tip oscillations without mercury.
  • Successful cell membrane piercing with minimal cell wall deformation at low injection speeds.
  • Achieved a high success rate (96%) and survival rate (80.7%) in zebrafish embryo injections.

Conclusions:

  • The developed piezo-driven cell injection system offers a safer and less damaging alternative to mercury-based methods.
  • This technology demonstrates significant potential for high-precision automated cell injection in various biotechnological applications.