Related Experiment Video

Updated: Jun 2, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Gout

Martin Underwood1

  • 1Warwick Medical School, University of Warwick, Coventry, UK.

BMJ Clinical Evidence
|May 18, 2011
PubMed

Insights

This systematic review evaluates treatments for acute gout and gout prevention. It found evidence on colchicine, NSAIDs, corticosteroids, and lifestyle advice for managing gout effectively.

Area of Science:

  • Rheumatology
  • Evidence-based Medicine
  • Clinical Pharmacology

Background:

  • Gout prevalence: approximately 5% of men and 1% of women.
  • High recurrence rate: up to 80% of patients experience recurrent gout attacks within 3 years.

Purpose of the Study:

  • To systematically review the effects of treatments for acute gout.
  • To assess treatments for preventing recurrent gout episodes in affected individuals.

Main Methods:

  • Systematic literature search of Medline, Embase, and The Cochrane Library up to September 2010.
  • Inclusion of 16 systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • GRADE evaluation of evidence quality for various interventions.

Main Results:

  • The review synthesizes evidence on the effectiveness and safety of multiple gout interventions.
  • Key interventions examined include colchicine, corticosteroids, and non-steroidal anti-inflammatory drugs (NSAIDs).
  • Lifestyle modifications such as weight loss and reduced alcohol/purine intake were also assessed.

Conclusions:

  • The review provides a comprehensive overview of current evidence on gout management.
  • Effectiveness and safety data are presented for pharmacological and non-pharmacological gout treatments.
  • This information aids in clinical decision-making for acute gout and prevention strategies.
Abstract

Related Concept Videos

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Gallbladder01:17

Gallbladder

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...