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Acquired and inherited thrombophilia disorders in pregnancy

Silvia S Pierangeli1, Benjamin Leader, Giuseppe Barilaro

  • 1Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch Galveston, TX 77555-0883, USA. sspieran@utmb.edu

Obstetrics and Gynecology Clinics of North America
|May 18, 2011
PubMed

Thromboembolism is the leading cause of antepartum and postpartum maternal mortality. The presence of antiphospholipid antibodies is responsible for many pregnancy losses and other morbidities in pregnant women, and is the most prevalent and treatable cause of acquired thrombophilia in pregnancy. There is also evidence that women with thrombophilia are at increased risk not only of pregnancy-related venous thromboembolism but other vascular pregnancy complications. Many studies have examined the association between thrombophilia and pregnancy complications. This article reviews the most up-to-date knowledge of prevalence, pathogenesis, and diagnosis of acquired and inherited thrombophilias and their relationship and association with pregnancy complications.

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