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Updated: Jun 1, 2026

11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
2-(4-Methoxy-phen-yl)-6-trifluoro-methyl-1H-pyrrolo[3,2-c]quinoline monohydrate
Abstract:
In the title compound, C(19)H(13)F(3)N(2)O·H(2)O, the phenyl and pyrroloquinoline ring system are close to coplanar [dihedral angle = 10.94 (4)°]. The meth-oxy group also is almost coplanar with the phenyl ring [5.4 (1)°]. In the crystal structure N-H⋯O(water) and water-quinoline O-H⋯N hydrogen bonds build up a supra-molecular chain-like arrangement along [001]. The remaining H atom of the water mol-ecule does not take part in classical hydrogen bonds. Instead, this O-H bond points toward the center of the phenyl ring of a neighbouring mol-ecule. Weak C-H⋯O and C-H⋯π inter-actions are also present.
