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Updated: Jun 1, 2026
09:26
Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
Published on: November 17, 2011
5α-Pregna-1,20-dien-3-one
Summary
A novel compound was isolated from soft coral Sinularia sp. This molecule features four trans-fused alicyclic rings with specific conformational details.
Area of Science:
- Marine Natural Products Chemistry
- Organic Chemistry
- Chemical Biology
Background:
- Soft corals, particularly from the Sinularia genus, are prolific sources of diverse bioactive secondary metabolites.
- Understanding the structural complexity of marine natural products is crucial for drug discovery and chemical biology.
Purpose of the Study:
- To isolate and elucidate the structure of a novel chemical entity from the soft coral Sinularia sp.
- To characterize the stereochemistry and conformational properties of the isolated compound.
Main Methods:
- Extraction and isolation of the title compound using chromatographic techniques.
- Structure elucidation through comprehensive spectroscopic analyses (NMR, MS).
- Conformational analysis using computational methods or advanced NMR techniques.
Main Results:
- Isolation of a new compound, C(21)H(30)O, from Sinularia sp.
- The molecule possesses a tetracyclic structure with all trans-fused alicyclic rings.
- Detailed conformational analysis revealed distorted chair conformations for the three six-membered rings and an envelope form for the five-membered ring.
Conclusions:
- The structural characterization of this novel compound expands the known chemical diversity of Sinularia metabolites.
- The unique conformational features may provide insights into the biosynthesis or biological activity of this class of compounds.
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