Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Preparation of Diols and Pinacol Rearrangement01:57

Preparation of Diols and Pinacol Rearrangement

Compounds bearing two hydroxyl groups are known as diols. When the hydroxyl groups are located on adjacent carbon atoms, the diols are called vicinal diols or glycols. Under acidic conditions, vicinal diols undergo a specific reaction called pinacol rearrangement.
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
Prodrugs01:30

Prodrugs

Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview01:07

Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview

In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two new polyketides from the mangrove endophytic fungus <i>Penicillium</i> sp. FDZ-018-102.

Natural product research·2026
Same author

Study on the mechanisms of action of <i>Ephedra sinica</i> Stapf extract in treating acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

Natural product research·2026
Same author

Optimisation and validation of capture mNGS for predicting antimicrobial resistance.

EBioMedicine·2026
Same author

Two new quaternary ammonium zwitterions from the noni juice and their anti-gout activities.

Natural product research·2026
Same author

Discovery and evaluation of a marine-derived chlorinated flavone derivative CHNQD-02204 as a potent and selective antifungal agent against Candida albicans.

European journal of medicinal chemistry·2026
Same author

Dimeric 2-(2-phenethyl)chromones from agarwood of Aquilaria malaccensis.

Phytochemistry·2026

Related Experiment Video

Updated: Jun 1, 2026

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
09:26

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Published on: November 17, 2011

5α-Pregna-1,20-dien-3-one.

Guang-Ying Chen, Mei-Yan Wei, Ni Tan

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary

    A novel compound was isolated from soft coral Sinularia sp. This molecule features four trans-fused alicyclic rings with specific conformational details.

    Area of Science:

    • Marine Natural Products Chemistry
    • Organic Chemistry
    • Chemical Biology

    Background:

    • Soft corals, particularly from the Sinularia genus, are prolific sources of diverse bioactive secondary metabolites.
    • Understanding the structural complexity of marine natural products is crucial for drug discovery and chemical biology.

    Purpose of the Study:

    • To isolate and elucidate the structure of a novel chemical entity from the soft coral Sinularia sp.
    • To characterize the stereochemistry and conformational properties of the isolated compound.

    Main Methods:

    • Extraction and isolation of the title compound using chromatographic techniques.
    • Structure elucidation through comprehensive spectroscopic analyses (NMR, MS).
    • Conformational analysis using computational methods or advanced NMR techniques.

    More Related Videos

    Lipidomics and Transcriptomics in Neurological Diseases
    09:58

    Lipidomics and Transcriptomics in Neurological Diseases

    Published on: March 18, 2022

    Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia
    03:22

    Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

    Published on: January 27, 2018

    Related Experiment Videos

    Last Updated: Jun 1, 2026

    Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
    09:26

    Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

    Published on: November 17, 2011

    Lipidomics and Transcriptomics in Neurological Diseases
    09:58

    Lipidomics and Transcriptomics in Neurological Diseases

    Published on: March 18, 2022

    Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia
    03:22

    Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

    Published on: January 27, 2018

    Main Results:

    • Isolation of a new compound, C(21)H(30)O, from Sinularia sp.
    • The molecule possesses a tetracyclic structure with all trans-fused alicyclic rings.
    • Detailed conformational analysis revealed distorted chair conformations for the three six-membered rings and an envelope form for the five-membered ring.

    Conclusions:

    • The structural characterization of this novel compound expands the known chemical diversity of Sinularia metabolites.
    • The unique conformational features may provide insights into the biosynthesis or biological activity of this class of compounds.