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Updated: Jun 1, 2026
08:43
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2,2,2-Tribromo-N-(2-chloro-phen-yl)acetamide
Summary
The crystal structure of a novel brominated and chlorinated organic compound was determined. Intramolecular hydrogen bonds involving N-H, Br, and Cl were observed in the solid state.
Area of Science:
- Crystallography
- Organic Chemistry
- Solid-State Chemistry
Background:
- Understanding the solid-state behavior of halogenated organic compounds is crucial for predicting their physical and chemical properties.
- The presence of multiple halogens and a nitrogen atom in organic molecules can lead to complex intermolecular interactions.
Purpose of the Study:
- To elucidate the crystal structure and intermolecular interactions of a novel compound with the chemical formula C(8)H(5)Br(3)ClNO.
- To investigate the conformational preferences and hydrogen bonding patterns in the solid state.
Main Methods:
- Single-crystal X-ray diffraction analysis was employed to determine the three-dimensional structure of the compound.
- Analysis of the crystal packing and interatomic distances to identify hydrogen bonding and other non-covalent interactions.
Main Results:
- The crystal structure of C(8)H(5)Br(3)ClNO was successfully determined.
- The N-H bond was found to adopt a syn conformation relative to the 2-chloro substituent on the benzene ring.
- No classical intermolecular hydrogen bonds were observed; however, intramolecular N-H⋯Br and N-H⋯Cl contacts were identified.
Conclusions:
- The study provides detailed structural information on a unique halogenated organic compound.
- Intramolecular hydrogen bonding plays a significant role in the solid-state conformation and stability of this molecule.
- The findings contribute to the understanding of halogen bonding and non-covalent interactions in organic crystals.
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