2-[2-(Trimethyl-silyl)eth-yl]isoindoline-1,3-dione
Ilia A Guzei1, Lara C Spencer, Uzma I Zakai
1Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, Wisconsin 53706, USA.
Summary
Researchers synthesized a novel silicon-containing compound for potential anti-cancer applications. Structural analysis revealed typical geometry and intermolecular interactions, including hydrogen bonding and pi-pi stacking, influencing crystal packing.
Area of Science:
- Organosilicon Chemistry
- Medicinal Chemistry
- Crystallography
Background:
- Silicon-containing compounds are explored for therapeutic potential, including anti-cancer properties.
- Understanding the structure-activity relationship is crucial for drug development.
Purpose of the Study:
- To synthesize and characterize a novel silicon-containing compound, C(13)H(17)NO(2)Si.
- To investigate the molecular and crystal structure of the synthesized compound.
Main Methods:
- Chemical synthesis of the title compound.
- X-ray crystallography to determine geometrical parameters and intermolecular interactions.
- Analysis of crystal packing and intermolecular forces (hydrogen bonding, pi-pi stacking).
Main Results:
- The silicon-containing compound C(13)H(17)NO(2)Si was successfully synthesized.
- Geometrical parameters, including the silicon atom's environment, were found to be typical.
- Molecules form dimers through C-H⋯O interactions and assemble into rows via π-π stacking (3.332(3) Å separation).
Conclusions:
- The synthesized compound exhibits standard structural features.
- Intermolecular interactions dictate the crystal packing, forming dimers and stacked rows.
- This structural characterization provides a foundation for further investigation into its potential anti-cancer activity.
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